重大

The brigadier was cashiered for his big mistake.

长因犯大错误而被革。

It is a discovery that made medical history.

这是载入医学史册的大发现。

Important changes are already in the pipeline.

大的变革已在酝酿之中。

Researchers believe that they are onto something big.

研究人员认为他们将有大发现。

The registry holds records of all major operations.

登记处有所有大手术的记录。

It's the big moment in my life.

这是我一生中的大时刻。

This was the greatest event in the annals of European integration.

这是欧洲统一史上最大的件。

She knew wherein her gross defects lay.

她知道自己的大缺点在哪里。

This is a significant contribution to knowledge.

这是对知识的大贡献。

He incurred a heavy loss through you.

他因为你而遭受大损失。

This is a book that displays the considerable scholarship of its author.

这是一本表现作者大学术成就的书。

The Government's decision is a real kick in the teeth for the unions.

政府的决定是对工会的大打击。

The present aspect of society is portentous of great change.

现在的社会预示着大变革的发生。

His accession to the important post was a big event.

他就任这一务是一个大件。

Her wedding was the event of the year.

她的婚礼是那一年的大件。

With the establishment of major new markets, the economy is thriving.

随着大新市场的建立，经济越来越兴旺。

Doctors are making great inroads in the fight against cancer.

在抗癌的战斗中医生正取得大进展。

The invention of the wheel was a milestone in the history of the world.

发明轮子是世界历史上的大件。

She views every minor setback as a disaster.

她把每个较小的挫折都看成大灾难。

Their boycott of the talks constitutes a serious impediment to peace negotiations.

他们联合抵制会谈的行为成了和谈的大障碍。