Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链克拉维酸生产能力,去除副产物头素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链发酵产生变溶素来消化双歧杆，提取质粒，并与商业化溶酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉菌克拉维酸生产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链霉菌发酵产生变溶菌素双歧杆菌细胞壁，提取质粒，并与商业溶菌酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉菌维酸生产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链霉菌发酵产生变溶菌素来消化双歧杆菌胞壁，提取质粒，并与商业化溶菌酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉菌克拉维酸生产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链霉菌发酵产生变溶菌素来消双歧杆菌细胞壁，提取质粒，并与业溶菌酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉菌克拉产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链霉菌发酵产变溶菌素来消化双歧杆菌细胞壁，提取质粒，并与商业化溶菌酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链克拉维酸生产能力,去除副产物头C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

法利用球孢链发酵产生变溶来消化双歧杆细胞壁，提取质粒，并与商业化溶酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链克拉维酸生产能力,去除副产物C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链发酵产生变溶来消化双歧杆细胞壁，提取质粒，并与商业化溶酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉克拉维酸生产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链霉产生变溶素来消化双歧杆胞壁，提取质粒，并与商业化溶酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉克拉维酸生产能力,去除副产物头霉C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

法利用球孢链霉发酵产生变溶来消化双歧杆细胞壁，提取质粒，并与商业化溶酶法比较。