NK cell will trigger effector functions(cytolysis) by KAR,if target cell loses appropriate ligands recognized by KIR.
如果靶胞失去KIR所识
,NK
胞即可通过KAR对靶
胞进行攻击。
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These granules contain some molecules that punch holes in the target cell's membrane by binding by binding directly to the phospholipids and creating pores. and some that cause target cells to undergo apoptosis, which is a programmed cell death.
这些颗粒内含一些能在胞膜上打孔的分子,它们直接
磷脂结合,然后穿孔;还有一些能够导致
胞凋亡,即程序性
胞死亡。