Now, Leptospira is a tiny spiral bacteria, that stains poorly with Gram staining, because it doesn't retain the Gram dyes well, so it's classically considered gram-negative.
Risk factors for leptospirosis include some professions, like people who work in rice-paddies, sugarcane plantations, or people who swim or wade in waters contaminated by animal urines.
科学快报-科学美国人2023Science Quickly, from SCIENTIFIC AMERICAN 2023
Lyme disease is primarily caused by a bacterium called Borrelia burgdorferi, which is transmitted by the bite of the blacklegged tick—more commonly known as the deer tick.
We were working on pan-coronavirus vaccines, sickle cell anemia gene therapy, malaria with people across the U.S. and in Africa, leptospirosis with people in southeast Asia, vaccines for peanut allergies.
If Leptospira gets to the kidneys, it may infect the interstitium, causing interstitial nephritis, or it may cause an inflammatory reaction that damages the renal tubules, resulting in acute tubular necrosis.