The version she has includes a gene that is resistant to colistin.

这种细中有一种基因可以抵御。

So, in this case, Klebsiella can be treated with colistin, tigecycline, or fosfomycin.

这种情况下，可以应用多、替加环或者磷霉来治疗。

Colistin is used only as a last measure, as the drug can cause organ damage.

由于会对人体器官造成伤害，因此不到万不得已，不会使用。

Then they brought in the slime mold.

然后他带来了。

He says the powerful antibiotic Colistin has become an important last line of defense.

他说，强效抗生已成为重要的最后一道防线。

It’s a strain of E. Coli bacteria that’s resistant to colistin, one of the strongest antibiotics we have.

它是一种肠杆株，对具有耐药性，是有的最强抗生之一。

The mutation makes the bug resistant to colistin , an antibiotic that’s considered the last line of defense.

这种突变使这种细对产生了耐药性，是一种被认为是最后一道防线的抗生。

Studying slime mold is, it's probably one of the weirdest organisms I've worked with.

- 研究是，它可能是接触过的最奇怪的生物之一。

Now, even Colistin is losing its power against highly resistant bacteria called " superbugs."

现在，即使是也失去了对抗被称为“超级细”的高度耐药细的能力。

What they found is that the slime molds actually build networks that are pretty close to optimal.

- 他发现，实际上建立了非常接近最佳的网络。

For some infected patients, their last hope is the antibiotic colistin, a toxic substance with potential side effects that include kidney and brain damage.

对一些受感染的病人来说，他最后的希望是抗生，这是一种有潜在副作用的有毒物质，包括肾脏和脑损伤。

Tom Frieden is the head of the U.S. Centers for Disease Control and Prevention. He says this new bug is resistant to every antibiotic available, including colistin.

美国疾病控制中心的主任汤姆·福里登称，该细可以抵御包括在内的任何医用抗生。

So we're talking about things that are is different from us as like a a sponge or even more different from us than a sponge, like something like a slime mold versus us.

所以谈论的是与不同的东西，比如海绵——甚至其差异比海绵跟的差异还的东西，譬如。

And combining the sugars with an antibacterial protein called polymyxin B, found in human saliva and potentially breast milk, made it better at poking holes in bacterial cell membranes to fight off infection.

并将糖与一种称为多 B 的抗蛋白结合在一起，这种蛋白存在于人类唾液和可能的母乳中， 可以更好地在细细胞膜上戳孔以抵抗感染。

It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.

肺炎克雷伯杆也是一种多重耐药，如果产生β-内酰胺酶，可以用头孢、氨基糖苷类、氟喹诺酮类以及碳青霉烯类药物治疗；如果产生ESBL，可以只应用碳青霉烯类进行治疗；如果产生碳青霉烯酶，则应用多、替加环或磷霉进行治疗。

What happened next is that, incredibly, the slime mold built a network of trails between the points that almost exactly mirrored Tokyo's actual railway system–a system which, by the way, is one of the most efficient in the world.

接下来发生的事情令人难以置信，在各个点之间建立了一个小路网络，几乎完全反映了东京的实际铁路系统——顺便说一句，这个系统是世界上最高效的系统之一。