A non-conservative substitution means that the new amino acid - valine, which is hydrophobic - has different properties than the one it replaced - glutamic acid, which is hydrophilic.
科学快报-科学美国人2023Science Quickly, from SCIENTIFIC AMERICAN 2023
Lyme disease is primarily caused by a bacterium called Borrelia burgdorferi, which is transmitted by the bite of the blacklegged tick—more commonly known as the deer tick.
And it turns out that microscopically rough surfaces tend to be more hydrophobic, because they can trap pockets of air and minimize the interaction between water droplets and the surface of the material.