General approaches involve the nucleophilic cycloalkylation, carbenoids addition of certain amino acid derivatives and derivatization from simple cyclopropane compounds.
Modified larch tannin was prepared by grafting copolymerization and sulfoalkylation, and successfully used as retanning agent, possessing good water solubility and enhanced penetration rate.
N butyl 2 ethoxy thioacridone was prepared from o chloro benzoic acid and p phenetidine by means of Ullman reaction,cyclization,N alkylation and sulfurization.
A new camphol sandaliol was synthetized by selective alkylation of isocamphol and phenol with acidic catalyst, and following hydrogenated in the presence of Raney nickel.
Because cancer cells multiply rapidly, they take in a high concentration of alkylating agents, and their DNA is frequently exposed and rarely repaired.
So they die off more often than most other cells, which have time to fix damaged DNA and don't accumulate the same concentrations of alkylating agents.