Cyanopyridine,intermediate of rimifon, was synthesized from 4-picoline using vanadium oxide as a catalyst in a fixed-bed reactor, reached 99% conversion of 4-picoline, 88% selectivity and 87.

以4甲基吡啶为原料,在固定床反应器中通过含的气固相接触氨反应制备雷米封中间体4氰基吡啶,4甲基吡啶的转率为99%,4氰基吡啶的选择性为88%,收率为87。