Now in addition to systolic heart failure, you've also got diastolic heart failure, which is where the heart's squeezing hard enough but not filling quite enough.
But when it came to constrictive bronchiolitis — the disease Miller believed he found in his biopsies — the agency stymied his efforts to create a criterion, he says.
However because calcium is also involved in cardiac myocyte contraction, these agents also reduce contractility of the heart and should not be used in case of systolic heart failures.
This can happen in two ways, either the heart's ventricles can't pump blood hard enough during systole, called systolic heart failure, or not enough blood fills the ventricles during diastole, called diastolic heart failure.
A normal ejection fraction is around 50-70%, between 40-50% would be borderline, and anything about 40% or less would indicate systolic heart failure because the heart is only squeezing out a little blood each beat.