So, more products started using phenylephrine.

因此，更多的产品开始使用去氧肾上腺素。

Fischman: Overall, though, if oral phenylephrine doesn't work, what should people use instead of it?

Fischman：不过，总的来说，如果口服去氧肾上腺素不起作用，人们应该用什么来代？

Phenylephrine was actually approved in the 1970s, so it had been around a while.

去氧肾上腺素实际上是在 20 世纪 70 年代获得批准的，所以已经存在了一段时间了。

They didn't review phenylephrine nasal sprays.

刘易斯：他们没有审查去氧肾上腺素鼻喷雾剂。

In addition to that, three trials of oral phenylephrine showed it was no better than a placebo at relieving congestion.

除此之外，三项口服去氧肾上腺素试验表明，在缓解充血方面并不比安慰剂更好。

Fischman: But I've been taking these cold medications with phenylephrine for years and they do make me feel better.

Fischman：但是我多年来一直服用这些感冒药和去氧肾上腺素，们确实让我感觉好多了。

And the pharmacologic data side indicated that when you take oral phenylephrine, most of it is metabolized to inactive forms, so very little of the active drug—in fact, one percent, based on FDA data—actually gets into the blood.

Le：药理数据方面表明，当您服用口服去氧肾上腺素时，大部分会被代谢为非活性形式，因此活性药物的含量极少（根据 FDA 数据，实际上只有 1%）真正进入血液。