If this happens, it causes Angelman syndrome, which results in severe intellectual diability, seizures, and ataxia.

如果此基因变，则导致安格尔曼综合征，患者出现严重的智力残疾、癫痫和共济失。

In fact, many different gene mutations have been identified each of which is known to cause different types of spinocerebellar ataxia.

实际上，目前已经鉴定出不同的基因变；每种变都会导致不同类型的脊髓小脑性共济失。

These mutations result in degenerative changes in the cerebellum and often in the spinal cord which causes progressive problems with coordination and balance known as ataxia.

这些变导致小脑和脊髓的退行性改变，这会导致进行性运动协、平衡等，称为共济失。

They typically die around 20 years later, of causes related to breathing or swallowing problems. The disorder is known as spino-cerebellar ataxia type 1, or SCA-1.

他们通常会在大约 20 年后死于与呼吸或吞咽问题有关的原因。这种疾病被称为 1 型脊髓小脑性共济失或 SCA-1。