Mr. Sabanayagam studies the epigenome as it relates to microgravity.

Sabanayagam研究了微重力组基因组。

After about a week the scientists take out the worms. They look for changes in the worms' epigenome.

一周后科学家将蠕虫取出，然后观察蠕虫观基因组改变。

The epigenome is kinda like Play-Doh on the genome.

观基因组有点像基因组上橡皮泥。

And that epigenome is constantly changing.

观基因组是不断变化。

The epigenome also mediates a lifelong dialogue between genes and the environment.

观基因组同介导终生对话在基因和环境中。

As twins get older, their epigenomes diverge, affecting the way they age and their susceptibility to disease.

当双胞胎慢慢长大，它们观基因组不一了，影响了他们寿命和他们受疾病损害程度。

The set of all of the chemical tags that are attached to the genome of a given cell is called the epigenome.

所有化学标记都依附于染色体组，属于一个特定细胞被称作是观基因组。

Think about developing therapies that target the epigenome.

想想开发靶向观基因组疗法。

The epigenome can be changed by the environment. And those changes pass from one generation of worms to the next.

观基因组可以被环境改变，这些改变从一代蠕虫传递到一代。

But in addition to the primary sequence of DNA, in addition to the As, Ts, Cs, and Gs, there's our epigenome.

但是了 DNA 初始，了 A，T，C 和 G，还有我们观基因组。

A balanced lifestyle that includes a healthy diet, exercise, and avoiding exposure to contaminants may in the long run create a healthy epigenome.

一个平衡生活方式包括健康饮食，锻炼，和避免暴露于污染从长远来看，能够创造一个健康观基因组。

Your mother's or your father's experiences as a child, or choices as adults, could actually shape your own epigenome.

你母亲或者父亲作为孩子经历，或者成为成年人后选择，事实上可能形成了你自己观基因组。

So they're essentially using Evo 2 to write messages in the language of the epigenome.

所以他们基本上是使用Evo 2用观基因组语言来写信息。

Each of the approximately 200 cell types in your body has essentially the same genome but its own distinct epigenome.

大约有200细胞类型在你身体里，每一个细胞类型都有相同染色体组但是拥有他们自己不同观基因组。

You mentioned that Evo2 can be used to control the epigenome, that layer of control on top of DNA that influences gene expression.

你提到Evo2可以用来控制观基因组，即DNA之上一层控制层，它影响基因达。

Right. But before we get too carried away with the possibilities, I want to touch upon something we discussed earlier: the epigenome.

对。但在我们被这些可能性冲昏头脑之前，我想谈谈我们之前讨论过事情：观基因组。

From its ability to predict mutations and generate new DNA sequences, to its potential for controlling the epigenome and even designing entire organisms.

从其预测突变和生成新DNA能力，到其控制观基因组甚至设计整个生物体潜力。

So when we're young, our epigenome is pristine, it's set with genes on and genes that  are off that maintain a cell's identity.

所以当我们年轻时候，我们观基因组是原始，它由维持细胞特性基因和关闭基因组成。

Precisely. They demonstrated the effectiveness of this technique in a remarkably creative way. They actually programmed Evo2 to write simple Morse code messages into the epigenome.

正是如此。他们以一种非常有创意方式证明了这项技术有效性。他们实际上对Evo2进行了编程，使其能够将简单摩尔斯电码信息写入观基因组。