Still in his mid-50s, he suffered severe osteoarthritis.

50多岁时候， 他就备受骨关节炎折磨。

Osteoarthritis is really common, and nearly everyone knows someone that suffers from it.

骨关节炎十分常见，几乎每个人身边都有该病患者。

Even the most common type, osteoarthritis, is trickier to prevent than one might think.

即使要避免最常见骨关节炎，也比人们难得多。

In arthritis, the patients usually have energy loss since fewer energy-carrying molecules are generated.

如果患有骨关节炎，由于新生载能分子较少，患者通常会产生能量损失。

Which can boost the risk of osteoarthritis and the need for hip replacement in middle age.

这会增加骨关节炎发病率从使得患病者在中年时需要进行髋关节置换手术。

With Osteoarthritis, we're really talking about one particular kind of joint which is a synovial joint.

骨关节炎中，我们讨论是一种特殊关节——滑膜关节。

The origins of osteoarthritis can often be traced to a patient's early life, from any seemingly ordinary joint injury.

骨关节炎病根，通常到患者早些年看似普通关节损伤。

Nowadays, it's thought that inflammation does indeed play an important role in the development of osteoarthritis.

现如今，炎症反应被认为确实在骨关节炎病程发展中，起到了不忽视作用。

We have, for example, an epidemic of osteoarthritis today.

例如，我们今天有流行骨关节炎。

The researchers looked for signs of diabetes, high blood pressure, and osteoarthritis.

研究人员寻找糖尿病、高血压和骨关节炎迹。

Dolly who had to be put down in 2003 had aged prematurely because she developed osteoarthritis at a relatively young age.

多利在相对年轻岁数患上骨关节炎，因此未老先衰，2003年不得不被实施安乐死。

And they actually randomized these women who had knee osteoarthritis into one of two groups.

戴维斯：他们实际上将这些患有膝骨关节炎女性随机分为两组。

People can also develop things called osteoarthritis, where you actually lose cartilage and you have more kind of bone on bone.

人们也以患上叫做骨关节炎病，你实际上失去了软骨，你骨头上有更多种类骨头。

The origins of osteoarthritis can often be traced to a patient’s early life, from any seemingly ordinary joint injury.

骨关节炎起源通常以到患者早年生活，源于任何看似普通关节损伤。

This leads to the flood of enzymes and degradation seen in osteoarthritis, but is driven by different inflammatory proteins called cytokines.

也出现骨关节炎中产生大量酶和削弱关节现，但由不同炎症蛋白引起，这种蛋白称为细胞因子。

If Dolly was a typical example, it was possible that clones would die early of age-related diseases, like osteoarthritis.

如果多莉是一个典型例子，克隆人有能会早死于与年龄有关疾病， 比如骨关节炎。

OA has long been considered the consequence of a 'wear and tear' process leading to loss of articular cartilage.

骨关节炎长期以来一直被认为是“磨损”过程结果，导致关节软骨丧失。

Finally, management and treatment of osteoarthritis can involve non-pharmacological approaches, like losing weight or moderate exercise, as well as physical therapy.

最后，骨关节炎治疗和处理常使用非药物疗法，如减肥或适当运动，以及物理疗法。

Here we show that FOS protein expression is increased in OA cartilage.

这里我们显示FOS蛋白在骨关节炎软骨中表达增加。

Higher rates of diabetes, hypertension, cardiovascular disease, even some cancers, osteoarthritis and a clear link to mental conditions such as depression.

糖尿病、高血压、心血管疾病，甚至某些癌症、骨关节炎发病率更高，并且与抑郁症等精神疾病有着明显联系。