One really serious complication with type 1 diabetes is called diabetic ketoacidosis, or DKA.

1型糖尿病有一种很严重并发症，叫作糖尿病酮症中毒，或DKA。

Like low levels of bicarbonate can cause metabolic acidosis with deep and labored breathing called Kussmaul breathing.

低水平碳氢盐会导致代中毒，伴随深大吸，称为Kussmaul吸。

We've got a diabetic ketoacidosis, let's go.

我们得了糖尿病酮症中毒，走吧。

They have a wide anion gap acidosis.

严重阴离子间隙增高中毒。

Diabetic ketoacidosis can happen even in people who've already been diagnosed with diabetes and currently have some sort of insulin therapy.

已被诊断糖尿病并开始接受胰岛素治疗患者也会产生糖尿病酮症中毒。

So other things start to build up in the blood as well, like potassium, called hyperkalemia, as well as acids, called metabolic acidosis.

因此其他物质也开始在血液中积：比如钾，造成高钾血症；还有，引起代中毒。

That's called — appropriately — muscle acidosis, and the drop in pH may be part of what causes the famous burn while you're exercising.

这被称为肌肉中毒，并且碱值下降可能是运动时肌肉燃烧部分原因。

And doctors have regularly smelled acetone on the breath of patients who are in a state of diabetic ketoacidosis and used it as a diagnostic.

而医生经常通过闻酮症中毒糖尿病患者吸中丙酮作为诊断方法。

If too little carbon dioxide is exhaled as a result of hypoventilation, body fluids tend to become more acid, a condition termed acidosis.

如果由于通气不足而二氧化碳太少，体液往往会变得更，这种情况称为中毒。

And, even though sodium bicarbonate can buffer metabolic acidosis, an event that increases muscle breakdown, no research has shown supplementation to improve muscle growth nor preserve muscle.

而且，尽管碳氢钠可以缓冲会增加肌肉损伤代中毒，但没有研究表明补充剂可以改善肌肉生长或保护肌肉。

In 1922 at the University of Toronto, the scientists went to a hospital ward full of diabetic children, most of them comatose and dying from diabetic keto-acidosis.

1922 年，在多伦多大学，科学家们去了一间满是糖尿病儿童医院病房，他们中大多数人昏迷不醒，死于糖尿病酮症中毒。

These ketone bodies are important because they can be used by cells for energy, but they also increase the acidity of the blood, which is why it's called keto-acid-osis.

这些酮体很重要，可被细胞用来获取能量，但他们也会增加血液，所以才叫作酮症中毒。

So in order to help compensate for an acidosis, hydrogen ions enter cells and potassium ions leave the cells and enter the blood, which might help with the acidosis, but results in hyperkalemia.

所以为了代偿中毒，氢离子被移入细胞内，而钾离子被移细胞而进入血中，这一机制缓解了中毒，但却导致了高钾血症。

In the case of health, sodium bicarbonate indeed has a solid track record largely thanks to its metabolic acidosis buffering, aiding the kidneys in acid-base balance and preventing bone mineral loss.

在健康方面， 有记录显示碳氢钠确实有助于健康，这在很大程度上归功于它代中毒缓冲作用，帮助肾脏碱平衡，防止骨矿物质流失。

Another situation is when living cells get affected by respiratory acidosis, which is when the carbon dioxide levels rise because a person isn't breathing or ventilating it out of the lungs quickly enough.

另一种情况是活细胞受到吸中毒影响，即一个人由于没有迅速吸排CO2，导致血中CO2水平上升。

Similarly, when there's a metabolic acidosis from excess organic acids like lactic acid and ketoacids, protons can enter cells with the organic anion rather than having to get exchanged for potassium ions.

相同地，当有机如乳和酮过多，产生代中毒时，质子会和有机阴离子一起进入细胞，而不是同钾离子交换。

Treatment of a DKA episode involves giving plenty of fluids, which helps with dehydration, insulin which helps lower blood glucose levels, and replacement of electrolytes, like potassium; all of which help to reverse the acidosis.

DKA治疗包括大量饮水以缓解脱水，使用胰岛素来降低血糖水平，以及补充电解质，如钾；这些都会缓解中毒。

Now, this isn't always the case for acidosis, though, for example, in respiratory acidosis, potassium levels aren't affected because CO2 is lipid soluble and freely moves into cells without being exchanged for potassium, therefore no hyperkalemia.

但是中毒情况并不都是如此，例如，在吸中毒时，钾离子水平不受影响，因为CO2是脂溶，可以自由进细胞不需要钾离子做交换，因此这种情况下，不会产生高钾血症。

Another cause of an internal potassium balance shift could be an acidosis, which is when the blood becomes too acidic, in other words, there's a higher concentration of hydrogen ions —which means a lower blood pH.

另一个打破内钾平衡原因是中毒，即血液成分过，换言之就是血液中氢离子浓度较高，导致血液pH值较低。

In HHS, you can sometimes see mild ketonemia and acidosis, but not to the extent that it's seen in DKA, and in DKA you can see some hyperosmolarity, so there is definitely overlap between these two syndromes.

HHS中，有时会现轻度酮血症和中毒，但不会进展到DKA那么严重；在DKA中，可看到一些高渗症状，所以上述两种综合征之间确实有部分相同症状。