Individuals with more severe forms of asthma might need additional treatments like daily corticosteroids, long-acting beta-adrenoceptor agonists, or leukotriene antagonists.
Second, cortisol starts cross-reacting with mineralocorticoid receptors, which normally only binds a related steroid hormone - mineralocorticoids which are secreted from the zona glomerulosa layer of the adrenal cortex.