The version she has includes a gene that is resistant to colistin.

这种细菌中有一种基因可以抵御粘菌素。

So, in this case, Klebsiella can be treated with colistin, tigecycline, or fosfomycin.

这种情况下，可以应用多粘菌素、替加环素或者磷霉素来治疗。

Colistin is used only as a last measure, as the drug can cause organ damage.

由于粘菌素会对人体器官造成伤害，因此不到万不得已，不会使用。

Then they brought in the slime mold.

然后他们带来了粘菌。

He says the powerful antibiotic Colistin has become an important last line of defense.

他说，强效抗生素粘菌素已成为重后一道防线。

It’s a strain of E. Coli bacteria that’s resistant to colistin, one of the strongest antibiotics we have.

它是一种肠杆菌菌株，对粘菌素具有，粘菌素是我们拥有强抗生素之一。

The mutation makes the bug resistant to colistin , an antibiotic that’s considered the last line of defense.

这种突变使这种细菌对粘菌素产生了，粘菌素是一种被认为是后一道防线抗生素。

Studying slime mold is, it's probably one of the weirdest organisms I've worked with.

- 研究粘菌是，它可能是我接触过奇怪生物之一。

Now, even Colistin is losing its power against highly resistant bacteria called " superbugs."

现在，即使是粘菌素也失去了对抗被称为“超级细菌”高度细菌能力。

What they found is that the slime molds actually build networks that are pretty close to optimal.

- 他们发现，粘菌实际上建立了非常接近佳网络。

For some infected patients, their last hope is the antibiotic colistin, a toxic substance with potential side effects that include kidney and brain damage.

对一些受感染病人来说，他们后希望是抗生素粘菌素，这是一种有潜在副作用有毒物质，包括肾脏和脑损伤。

Tom Frieden is the head of the U.S. Centers for Disease Control and Prevention. He says this new bug is resistant to every antibiotic available, including colistin.

美国疾病控制中心主任汤姆·福里登称，该细菌可以抵御包括粘菌素在内任何医用抗生素。

So we're talking about things that are is different from us as like a a sponge or even more different from us than a sponge, like something like a slime mold versus us.

所以我们谈论是与我们不同东西，比如海绵——甚至其差异比海绵跟我们差异还东西，譬如粘菌。

And combining the sugars with an antibacterial protein called polymyxin B, found in human saliva and potentially breast milk, made it better at poking holes in bacterial cell membranes to fight off infection.

并将糖与一种称为多粘菌素 B 抗菌蛋白结合在一起，这种蛋白存在于人类唾液和可能母乳中， 可以更好地在细菌细胞膜上戳孔以抵抗感染。

It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.

肺炎克雷伯杆菌也是一种多重菌，如果产生β-内酰胺酶，可以用头孢菌素、氨基糖苷类、氟喹诺酮类以及碳青霉烯类物治疗；如果产生ESBL，可以只应用碳青霉烯类进行治疗；如果产生碳青霉烯酶，则应用多粘菌素、替加环素或磷霉素进行治疗。

What happened next is that, incredibly, the slime mold built a network of trails between the points that almost exactly mirrored Tokyo's actual railway system–a system which, by the way, is one of the most efficient in the world.

接下来发生事情令人难以置信，粘菌在各个点之间建立了一个小路网络，几乎完全反映了东京实际铁路系统——顺便说一句，这个系统是世界上高效系统之一。