If this happens, it causes Angelman syndrome, which results in severe intellectual diability, seizures, and ataxia.

如果此基因，则导尔曼综合征，患者出现严重的智力残疾、癫痫和共济失调。

In fact, many different gene mutations have been identified each of which is known to cause different types of spinocerebellar ataxia.

实际上，目前已经鉴定出不同的基因；每种都会导不同类型的脊髓小脑性共济失调。

These mutations result in degenerative changes in the cerebellum and often in the spinal cord which causes progressive problems with coordination and balance known as ataxia.

些导小脑和脊髓的退行性，会导进行性运动协调障碍、平衡障碍等，称为共济失调。

They typically die around 20 years later, of causes related to breathing or swallowing problems. The disorder is known as spino-cerebellar ataxia type 1, or SCA-1.

他们通常会在大约 20 年后死于与呼吸或吞咽问题有关的原因。种疾病被称为 1 型脊髓小脑性共济失调或 SCA-1。