重大

The brigadier was cashiered for his big mistake.

旅长因犯错误而被革职。

It is a discovery that made medical history.

载入医学史册的发现。

Important changes are already in the pipeline.

的变革已在酝酿之中。

Researchers believe that they are onto something big.

研究人员认为他们将有发现。

The registry holds records of all major operations.

登记处有所有手术的记录。

It's the big moment in my life.

我一生中的刻。

This was the greatest event in the annals of European integration.

欧洲统一史上最的件。

She knew wherein her gross defects lay.

她知道自己的缺点在哪。

This is a significant contribution to knowledge.

对知识的贡献。

He incurred a heavy loss through you.

他因为你而遭受损失。

This is a book that displays the considerable scholarship of its author.

一本表现作者学术成就的书。

The Government's decision is a real kick in the teeth for the unions.

政府的决定对工会的打击。

The present aspect of society is portentous of great change.

现在的社会预示着变革的发生。

His accession to the important post was a big event.

他就任一要职务一个件。

Her wedding was the event of the year.

她的婚礼那一年的件。

With the establishment of major new markets, the economy is thriving.

随着新市场的建立，经济越来越兴旺。

Doctors are making great inroads in the fight against cancer.

在抗癌的战斗中医生正取得进展。

The invention of the wheel was a milestone in the history of the world.

发明轮子世界历史上的件。

She views every minor setback as a disaster.

她把每个较小的挫折都看成灾难。

Their boycott of the talks constitutes a serious impediment to peace negotiations.

他们联合抵制会谈的行为成了和谈的障碍。