Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉菌克拉维酸力,去除副头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链霉菌发酵变溶菌素来消化双歧杆菌细胞壁，提取质粒，并与商业化溶菌酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉克拉维酸生产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利链霉发酵产生变溶素来消化双歧杆细胞壁，提取质粒，并与商业化溶酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链克拉维酸生产能力,去除副产物头素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链酵产生变溶素来消化双歧杆细胞壁，提取质粒，并与商业化溶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉菌克拉维酸产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法孢链霉菌发酵产变溶菌素来消化双歧杆菌细胞壁，提取质粒，并与商业化溶菌酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状克拉维酸生产能力,去除副产物头素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢发酵产生变溶素来消化双歧杆细胞壁，提取质粒，并与商业化溶酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目高棒状霉克拉维酸生产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢霉发酵产生变溶素来消化双歧杆细胞壁，粒，并与商业化溶酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉菌克拉维酸产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链霉菌发酵产溶菌素来消化双歧杆菌胞壁，提取质粒，并与商业化溶菌酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链霉菌克拉维酸生产能力,去除副产物头霉素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链霉菌发酵产生菌素来消化双歧杆菌细胞壁，提取质粒，并与商业化菌酶法比较。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目高棒状克拉维酸生产能力,去除副产物头素C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢发酵产生变溶素来消化双歧杆细，取质粒，并与商业化溶酶法比较。