To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

用放免法测定男性更年期高血压病患及对照的血清睾酮(T)、孕酮(P)、雌二醇(E2)水平。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利用亲属睾丸作供体行同种异体睾丸移植4例,其中医源性无睾症2例,原发性性腺机能低下2例,术后观察患血清睾酮水平、第二性征变化及性功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二酮的转化产生菌偶发分枝杆菌MF2出发,经紫外诱变结合平板筛选,获得一株主要转化生产睾酮的突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

结论氟他胺通过对生成睾酮细胞器的毒性损害和的抑制，降低了睾酮的分泌量，从而阻碍了性分化和性发育。

To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

用放免法测定男性更年期高血压病患及对照的血清酮(T)、孕酮(P)、雌二醇(E2)水平。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利用亲属供体行同种异体移植4例,其中医源性无症2例,原性性腺机能低下2例,术后观察患血清酮水平、第二性征变化及性功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二酮的转化产生菌偶分枝杆菌MF2出,外诱变结合平板筛选,获得一株主要转化生产酮的突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

结论氟他胺通过对生成酮细胞器的毒性损害和关键酶的抑制，降低了酮的分泌量，从而阻碍了性分化和性育。

To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

用放免法测定男更年期高血压病患及对照的血清睾酮(T)、孕酮(P)、雌二醇(E2)水平。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利用亲属睾丸作供体行同种异体睾丸移植4例,其中医源无睾症2例,原发腺机能低下2例,术后观察患血清睾酮水平、第二征变化及功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二酮的转化产生菌偶发分枝杆菌MF2出发,经紫外诱变结合平板筛选,获得一株主要转化生产睾酮的突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

结论氟他胺通过对生成睾酮细胞器的毒和关键酶的抑制，降低了睾酮的分泌量，从而阻碍了分化和发育。

To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

放免法测定男性更年期高血压病患及对照血清睾酮(T)、孕酮(P)、雌二醇(E2)水平。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利亲属睾丸作供体行同种异体睾丸移植4例,其中医源性无睾症2例,原发性性腺机能低下2例,术后观察患血清睾酮水平、第二性征变化及性功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二酮转化产生菌偶发分枝杆菌MF2出发,经紫外诱变结合平板筛选,获得一株主要转化生产睾酮突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

结论氟他胺通过对生成睾酮细毒性损害和关键酶抑制，降低了睾酮分泌量，从而阻碍了性分化和性发育。

To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

用放免法测定男性更年期高血压病患及对照的血清睾酮(T)、孕酮(P)、雌二醇(E2)水平。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利用亲属睾丸作供种异睾丸移植4例,其中医源性无睾症2例,原发性性腺机能低下2例,术后观察患血清睾酮水平、第二性征变化及性功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二酮的转化产生偶发分MF2出发,经紫外诱变结合平板筛选,获得一株主要转化生产睾酮的突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

结论氟他胺通过对生成睾酮细胞器的毒性损害和关键酶的抑制，降低了睾酮的分泌量，从而阻碍了性分化和性发育。

To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

用放免法测定男性更年期高血压病患及对照的血清睾(T)、孕(P)、雌二醇(E2)。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利用亲属睾丸作供体行同种异体睾丸移植4,其中医源性无睾症2,原发性性腺机能低下2,观察患血清睾、第二性征变化及性功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二的转化产生菌偶发分枝杆菌MF2出发,经紫外诱变结合板筛选,获得一株主要转化生产睾的突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

结论氟他胺通过对生成睾细胞器的毒性损害和关键酶的抑制，降低了睾的分泌量，从而阻碍了性分化和性发育。

To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

用放免法测定男性更年期高压病患及对照睾酮(T)、孕酮(P)、雌二醇(E2)水平。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利用亲属睾丸作供体行同种异体睾丸移植4例,其中医源性无睾症2例,原发性性腺机能低下2例,术后观察患睾酮水平、第二性征变及性功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二酮产菌偶发分枝杆菌MF2出发,经紫外诱变结合平板筛选,获得一株主要产睾酮突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

结论氟他胺通过对成睾酮细胞器毒性损害和关键酶抑制，降低了睾酮分泌量，从而阻碍了性分和性发育。

To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

用放免法测定男性更年期高血压病患及对照的血清睾酮(T)、孕酮(P)、雌二醇(E2)水。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

法用亲属睾丸作供体行同种异体睾丸移植4例,其中医源性无睾症2例,原发性性腺机能低下2例,术后观察患血清睾酮水、第二性征变化及性功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二酮的转化产生菌偶发分枝杆菌MF2出发,经紫外诱变板筛选,获得一株主要转化生产睾酮的突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

论氟他胺通过对生成睾酮细胞器的毒性损害和关键酶的抑制，降低了睾酮的分泌量，从而阻碍了性分化和性发育。

To detect the blood serum testosterone(T),pregnendione(P) and estradiol(E2)levels of the male patients with climacteric hypertension and the control group by radioimmunoassay.

用放免法测定男性更年期高压病患及对照清睾酮(T)、孕酮(P)、雌二醇(E2)水平。

Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利用亲属睾丸作供体行同种异体睾丸移植4例,其中医源性无睾症2例,原发性性腺机能低下2例,术后观察患清睾酮水平、第二性征变及性功能情况。

A mutant, TS-N-121 was obtained by mutation and plate screening from a parent strain Mycobacterium fortuitum MF2 , which could transform sterol into androstanedione as the main product.

从雄甾二酮转菌偶发分枝杆菌MF2出发,经紫外诱变结合平板筛选,获得一株主要转睾酮突变株TS-N-121。

Conclusions Flutamide can cut down the secretory volume of T to block the sexual differentiation and development by the venenous harm on cellular organ and the restrained activity of key enzyme.

结论氟他胺通过对成睾酮细胞器毒性损害和关键酶抑制，降低了睾酮分泌量，从而阻碍了性分和性发育。